2007: The Food and Drug Administration first raised concern about incretin mimetics in 2007. They warned that incretin mimetics, especially exenatide (Byetta and Byuderon) and sitagliptin (Janumet and Januvia), could cause pancreatic diseases. The warning followed reports that a rising number of incretin mimetics users were being diagnosed with acute pancreatitis and pancreatic cancer.
Reference: “FDA Investigating Reports of Possible Increased Risk of Pancreatitis..” U.S. Food and Drug Administration, FDA, www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-fda-investigating-reports-possible-increased-risk-pancreatitis-and-pre.
