1988 โ In 1988, Zantac became the worldโs best selling drug and one of the first drugs to ever top $1 billion in annual sales.
Reference:ย โTimeline: Popular Heartburn Medicine Zantac Pulled off Store Shelves.โ Reuters, Thomson Reuters, 21 Oct. 2019, www.reuters.com/article/us-health-fda-heartburn-timeline/timeline-popular-heartburn-medicine-zantac-pulled-off-store-shelves-idUSKBN1X014E.